Definition of "cobblestoned"

Wandering away from the entrance to the restaurant, Sam stood by the fountain in the old cobblestoned square, looking at the church of Santa Maria...

1961, Morley Callaghan, A passion in Rome

But, beyond gross morphologic observations this is purely speculative and not tested by studies in cobblestoned monolayers.

2005, Carolyn E Patterson, Perspectives on lung endothelial barrier function