Definition of "irritate"

If thou irritatest my lord, there will come to war against thee all the Getulians, Numidians, and Garamantes, Afric contains.

1814, Signor Vestris, La Didone Abbandonata, a Serious Opera, in Two Acts. Altered from Metastasio, by Signor Vestris. As Represented at the King’s Theatre, in the Hay-Market., London: […] J. Gillet, […], page 15

Thou scandalizest me and irritatest my nature as much as it possibly can be irritated.

1896, Ernest Rénan, translated by Eleanor Grant Vickery, Caliban: A Philosophical Drama Continuing “The Tempest” of William Shakespeare (Publications of The Shakespeare Society of New York; No. 9), New York, N.Y.: The Shakespeare Press; London: Kegan Paul, Trench, Trübner & Co., Ltd., page 19

Thanks to that penny he had just spent so recklessly [on a newspaper] he would pass a happy hour, taken, for once, out of his anxious, despondent, miserable self. It irritated him shrewdly to know that these moments of respite from carking care would not be shared with his poor wife, with careworn, troubled Ellen.

1913, Mrs. [Marie] Belloc Lowndes, chapter I, in The Lodger, London: Methuen; republished in Novels of Mystery: The Lodger; The Story of Ivy; What Really Happened, New York, N.Y.: Longmans, Green and Co., […], page 10

Are human laws presently superfluous, so often as they do not irritate or abrogate Divine laws ?

c. 1634-1661 John Bramhall, Protestants' Ordination Defended